Correlation of water absorption with tablet disintegration time
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Correlation of water absorption with tablet disintegration time by Norman Fredrick Billups

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Published .
Written in English

Subjects:

  • Tablets (Medicine).

Book details:

Edition Notes

Statementby Norman Fredrick Billups.
The Physical Object
Pagination54 leaves, bound :
Number of Pages54
ID Numbers
Open LibraryOL14298487M

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Wetting time, disintegration time, and water absorption ratio The WT of the ODTs was found to be directly related to the water AR of the tablets except for PPA containing tablets [ Figure 3 ]. Linear regression analysis of WT (WT) and water AR of all tablets formulated showed a coefficient of determination (R 2) value of when the value. One tablet is placed into each tube and the time to disintegrate and fall through the screen is noted.(see Ansel page ) Dissolution Like the disintegration test the dissolution test does not prove that the dosage form will release the drug in vivo in a specific manner but it . The Enslin – Neff device can be used for measuring the water absorption rate of the tablets. From the volume difference of the absorbed liquid and the wetting time, the water absorption rate can. Pharmaceutics Effect of a Disintegration Mechanism on Wetting, Water Absorption, and Disintegration Time of Orodispersible Tablets Pabari RM, Ramtoola Z School of Pharmacy, Royal College of Surgeons in Ireland, , St. Stephens Green, Dublin 2, Ireland Dr. Zebunnissa Ramtoola [email protected] ABSTRACT The aim ofthis study was to evaluate the influence of disintegration mechanism ofvarious Cited by:

their disintegration and/or dissolution time is critical Effect of a Disintegration Mechanism on Wetting, Water Absorption, and Disintegration Time of Orodispersible Tablets Pabari RM, Ramtoola Z School of Pharmacy, Royal College of Surgeons in Ireland, , St. Stephens Green, Dublin 2, Ireland. (Good – decrease in disintegration time, Poor – increase in disintegration time) Sodium lauryl sulphate increased absorption of water by starch or had a variable effect on water penetration in tablets. Surfactants are only effective within certain concentration ranges. Disintegration and dissolution rate of disintegrants with moderate swelling capacity depend to a large extent on mixing time of drug/excipient preblended with lubricant. On other hand, disintegrants with strong swelling capacity such as sodium starch glycolate were hardly affected by mixing time with lubricant. Size: 67KB. The method described above, being comprised of seven pages including Figures I and II and identified as DO, Determination of Disintegration Time of Tablets and dated July 5, , is hereby designated the "official method" referred to in Section C of the Food and Drug Regulations.

  ORAL DISINTEGRATION / DISPERSIBLE TABLET Appearance Hardness / Crushing strength Weight variation Thickness Friability Disintegration Time Dissolution test Water absorption ratio Wetting time 32 The results from the USP disintegration test do not provide a strong correlation with in vivo disintegration times in the mouth because the. The tablet or capsule may be passed intact in the feces, especially in older people. Controlled-release formulations Some drug products are specially formulated to release their active ingredients slowly or in repeated small amounts over time—usually for a period of 12 hours or more. Investigations have proved that in the case of po preparations disintegration time, dissolution rate and in vivo absorption rate are closely interrelated. These correlations described by adequate mathematical formulas are valid in the case of papaverine, drotaverine and Depogen--compounds with benzyl-isoquinoline : Marton S, Szentmiklósi P, Rácz I. Where, Wa = weight of tablet after water absorption & Wb = weight of tablet before water absorption. Dispersion Time9, 13 Tablet was added to 10 ml of water and time required for complete dispersion was measured. Three tablets from each formulation were randomly selected and Dispersion time was performed. Disintegration Time15 The.